HCID 66592460, compound → 1-(1-Fluoro-2-methylpropan-2-yl)piperazine

HRID 1091306Notes

Reaction equation

HRID 1091306 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]([CH3:21])([CH3:20])[CH2:18][F:19])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[CH3:21][C:17]([N:14]1[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]1)([CH3:20])[CH2:18][F:19]

Participants

4

Reactant 1

HCID 66592460HCID 66592460, compound

Product 1

HCID 575860431-(1-Fluoro-2-methylpropan-2-yl)piperazineYield 66%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

4-(1,1-Dimethyl-2-fluoroethyl)piperazine-1-carboxylic acid benzyl ester (270 mg, 0.92 mmol) was dissolved in ethanol (20 mL), and 10% palladium hydroxide/carbon (100 mg) was added thereto. The mixture was stirred for two days at room temperature under a hydrogen stream at normal pressure. The catalyst was separated by filtration, and then the reaction liquor was concentrated under reduced pressure, and dried to obtain the title compound (97 mg, 66%) as an oily matter. This compound was used in the subsequent reaction without performing further purification.

Workup

  1. customThe catalyst was separated by filtration
  2. concentrationthe reaction liquor was concentrated under reduced pressure
  3. customdried

Sources & evidence

ORD record
ord-2535447a3f624fa795eb2d5d2bff3578
Source dataset
uspto-grants-2012_03
Patent number
US08129366B2

Reaction notes

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