1,4-Dioxane hydrochloride → HCID 66592243, compound

HRID 1091310Notes

Reaction equation

HRID 1091310 reaction equation
C(OC([N:8]1[CH2:13][C@@H:12]2[CH2:14][C@H:9]1[CH2:10][N:11]2[CH:15]1[CH2:17][CH2:16]1)=O)(C)(C)C.[ClH:18].O1CCOCC1>>[ClH:18].[ClH:18].[CH:15]1([N:11]2[CH2:10][C@@H:9]3[CH2:14][C@H:12]2[CH2:13][NH:8]3)[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 66592127HCID 66592127, compound

Product 1

HCID 66592243HCID 66592243, compoundYield 85%

Procedure

4N—HCl/1,4-dioxane (10 mL) was added to (1S,4S)-(−)-2-cyclopropyl-2,5-diazabicyclo[2.2.1]heptan-5-ylcarboxylic acid tert-butyl ester (4.46 g, 18.71 mmol), and the mixture was stirred for 7 hours at room temperature. The reaction liquor was concentrated under reduced pressure, to obtain the title compound (3.34 g, 85%) as an oily matter.

Workup

  1. concentrationThe reaction liquor was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2614e28884da4e5bb11244830e2d78af
Source dataset
uspto-grants-2012_03
Patent number
US08129366B2

Reaction notes

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