Hydrochloric Acid → HCID 66589561, compound

HRID 1091326Notes

Reaction equation

HRID 1091326 reaction equation
[O:1]=[C:2]1[CH:7]([N:8]2[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH2:17][NH:18][C:19](=[O:45])[NH:20][C:21]4[CH:22]=[CH:23][C:24]([CH3:44])=[C:25]([CH:43]=4)[O:26][C:27](=[O:42])[CH2:28][N:29]4[CH2:34][CH2:33][N:32](C(OC(C)(C)C)=O)[CH2:31][CH2:30]4)[CH:14]=3)[C:9]2=[O:46])[CH2:6][CH2:5][C:4](=[O:47])[NH:3]1.[ClH:48]>C(Cl)Cl.CCOCC>[ClH:48].[N:29]1([CH2:28][C:27]([O:26][C:25]2[CH:43]=[C:21]([NH:20][C:19]([NH:18][CH2:17][C:13]3[CH:14]=[C:15]4[C:10](=[CH:11][CH:12]=3)[C:9](=[O:46])[N:8]([CH:7]3[CH2:6][CH2:5][C:4](=[O:47])[NH:3][C:2]3=[O:1])[CH2:16]4)=[O:45])[CH:22]=[CH:23][C:24]=2[CH3:44])=[O:42])[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66589469HCID 66589469, compound

Product 1

HCID 66589561HCID 66589561, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a mixture of tert-butyl 4-(2-(5-(3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)ureido)-2-methylphenoxy)-2-oxoethyl)piperazine-1-carboxylate (0.65 g, 1.0 mmol) in methylene chloride (50 mL) is added 2M HCl in ether (1 mL), and the mixture will be stirred for 24 hrs. The solid precipitate is filtered, rinsed with DCM (10 mL), and dried under vacuum to provide the product.

Workup

  1. filtrationThe solid precipitate is filtered
  2. washrinsed with DCM (10 mL)
  3. customdried under vacuum
  4. customto provide the product

Sources & evidence

ORD record
ord-8f7591a3273f47a284019c0aa2ab79db
Source dataset
uspto-grants-2012_03
Patent number
US08129375B2

Reaction notes

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