Hydrochloric Acid → 6-acetamido-N-(8-morpholin-4-yl-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyridine-3-carboxamide;hydrochloride

HRID 1091537Notes

Reaction equation

HRID 1091537 reaction equation
[C:1]([NH:4][C:5]1[CH:32]=[CH:31][C:8]([C:9]([NH:11][C:12]2[N:21]3[CH2:22][CH2:23][N:24]=[C:20]3[C:19]3[CH:18]=[CH:17][C:16]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)=[CH:15][C:14]=3[N:13]=2)=[O:10])=[CH:7][N:6]=1)(=[O:3])[CH3:2].[ClH:33]>O1CCOCC1>[ClH:33].[C:1]([NH:4][C:5]1[CH:32]=[CH:31][C:8]([C:9]([NH:11][C:12]2[N:21]3[CH2:22][CH2:23][N:24]=[C:20]3[C:19]3[CH:18]=[CH:17][C:16]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)=[CH:15][C:14]=3[N:13]=2)=[O:10])=[CH:7][N:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178474220HCID 178474220, compound

Product 1

HCID 1784742216-acetamido-N-(8-morpholin-4-yl-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyridine-3-carboxamide;hydrochlorideYield 78%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a mixture of 6-(acetamido)-N-[8-(morpholin-4-yl)-2,3-dihydroimidazo[1,2-c]-quinazolin-5-yl]nicotinamide (Example 2-3) 20.0 mg (0.046 mmol) in 1,4-dioxane 1.5 mL was added 4N HCl in 1,4-dioxane 0.5 mL and stirred at room temperature for 40 minutes. The precipitate was collected and washed with diethyl ether to give the title compound 17.0 mg as yellow solid. Yield 78%.

Workup

  1. customThe precipitate was collected
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-8c52d6f54dbb47e0bcf862522ea08344
Source dataset
uspto-grants-2012_03
Patent number
US08129386B2

Reaction notes

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