反应详情

0.1 g (0.16 mmol) of intermediate 1d and 115 mg (0.65 mmol) of 1-(6-methylpyridin-2-yl)piperazine were stirred in 3 ml of DMF at 100° C. for 20 minutes. The reaction mixture was then poured into 30 ml of ice-water/K2CO3. The resulting precipitate was isolated and crystallized from a little methanol, resulting 0.1 g of the product.

1. customThe resulting precipitate was isolated
2. customcrystallized from a little methanol