1-Methylpiperazine → (2-Chloro-4-trifluoromethylpyrimidin-5-yl)(4-methylpiperazin-1-yl)methanone

Participants

Reaction Steps

N-Methylpiperazine (0.11 mL, 1 mmol) was added to a solution of 2-chloro-4-trifluoromethyl-pyrimidine-5-carbonyl chloride (0.24 g, 1 mmol) in DCM (4 mL) at 0° C. The mixture was stirred at that temperature for 1 hr, and the solvent was then removed under vacuum to give (2-chloro-4-trifluoromethylpyrimidin-5-yl)(4-methylpiperazin-1-yl)methanone as a solid.

Provenance & Evidence