1-Methylpiperazine → (2-Chloro-4-trifluoromethylpyrimidin-5-yl)(4-methylpiperazin-1-yl)methanone

HRID 1091631Notes

Reaction equation

HRID 1091631 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Cl:8][C:9]1[N:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[C:12]([C:19](Cl)=[O:20])=[CH:11][N:10]=1>C(Cl)Cl>[Cl:8][C:9]1[N:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[C:12]([C:19]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)=[O:20])=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 27367082-Chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl chloride

Product 1

HCID 86640516(2-Chloro-4-trifluoromethylpyrimidin-5-yl)(4-methylpiperazin-1-yl)methanone

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-Methylpiperazine (0.11 mL, 1 mmol) was added to a solution of 2-chloro-4-trifluoromethyl-pyrimidine-5-carbonyl chloride (0.24 g, 1 mmol) in DCM (4 mL) at 0° C. The mixture was stirred at that temperature for 1 hr, and the solvent was then removed under vacuum to give (2-chloro-4-trifluoromethylpyrimidin-5-yl)(4-methylpiperazin-1-yl)methanone as a solid.

Workup

  1. customthe solvent was then removed under vacuum

Sources & evidence

ORD record
ord-cd88129a9932471691a893eb2c828d3e
Source dataset
uspto-grants-2012_03
Patent number
US08129396B2

Reaction notes

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