反应详情

To a solution of 2-((4-(aminomethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-6-methylthieno[2,3-d]pyrimidin-4(3H)-one (0.087 mmol, 30 mg) and DIPEA (0.175 mmol, 0.029 ml, 22.59 mg) in DCM (1 mL) was added acetyl chloride (0.175 mmol, 0.012 ml, 13.72 mg). The whole was stirred at room temperature overnight before the reaction mixture was concentrated under reduced pressure and the residue purified by reverse phase HPLC to give a white solid (8.7 mg, 23 mmol. 25.8%)

1. concentrationwas concentrated under reduced pressure
2. customthe residue purified by reverse phase HPLC
3. customto give a white solid (8.7 mg, 23 mmol. 25.8%)