Methanol → 1-Cyclopropylpiperazine

HRID 1092090Notes

Reaction equation

HRID 1092090 reaction equation
Cl.Cl.[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1.CO>O>[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 887MethanolHCID 212208121-Cyclopropylpiperazine dihydrochloride

Product 1

HCID 47420041-CyclopropylpiperazineYield 84.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-Cyclopropylpiperazine dihydrochloride (1.493 g, 7.5 mmol) was dissolved in water (5.00 mL) and methanol (5.00 mL) and converted to its freebase by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 3.5M ammonia in methanol and pure fractions were evaporated to dryness to afford 1-cyclopropylpiperazine (0.796 g, 84%) as an oil.

Workup

  1. washThe desired product was eluted from the column
  2. customwere evaporated to dryness

Sources & evidence

ORD record
ord-b75b92e4cb974be5b8496b6afd230492
Source dataset
uspto-grants-2012_03
Patent number
US08129391B2

Reaction notes

Loading…