反应详情

65.08 g (0.195 mol, 2 eq) of methyl (triphenylphosphoranylidene)acetate are added to a solution of 29.60 g (0.097 mol, 1 eq) of 3-butoxy-4-iodobenzaldehyde in 360 ml of toluene. The reaction mixture is refluxed for 2 hours. The solvent is evaporated off and the oil obtained is chromatographed on silica gel (50/50 heptane/dichloromethane). 30.47 g of methyl(E)-3-(3-butoxy-4-iodophenyl)acrylate are obtained in the form of pale yellow crystals. Yield=87%.

1. temperatureThe reaction mixture is refluxed for 2 hours
2. customThe solvent is evaporated off
3. customthe oil obtained
4. customis chromatographed on silica gel (50/50 heptane/dichloromethane)