Hydrochloric Acid → HCID 24965150, compound

Participants

Reaction Steps

1—This material was obtained as described in example 23 from 1-adamantan-2-yl-4-isopropyl-1,3-dihydro-imidazol-2-one (obtained in example 8, 100 mg) by alkylation with 2-chloromethylpyridine hydrochloride (73 mg) with the following modification: 2.5 equivalents of NaH dispersion (42 mg) was used such as to compensate for the HCl content in the alkylating agent. 1-Adamantan-2-yl-4-isopropyl-3-pyridin-2-ylmethyl-1,3-dihydro-imidazol-2-one was obtained as a light yellow gum (64 mg). MS (ESI): 352.2 (MH+).

Provenance & Evidence