Hydrochloric Acid → HCID 24965150, compound

HRID 1092307Notes

Reaction equation

HRID 1092307 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[N:11]1[CH:15]=[C:14]([CH:16]([CH3:18])[CH3:17])[NH:13][C:12]1=[O:19])[CH2:8]2.Cl.Cl[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=1.[H-].[Na+].Cl>>[CH:1]12[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH:2]1[N:11]1[CH:15]=[C:14]([CH:16]([CH3:17])[CH3:18])[N:13]([CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)[C:12]1=[O:19])[CH2:10]2

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 23392Picolyl chloride hydrochlorideHCID 24758Sodium hydrideHCID 24964431HCID 24964431, compound

Product 1

HCID 24965150HCID 24965150, compound

Procedure

1—This material was obtained as described in example 23 from 1-adamantan-2-yl-4-isopropyl-1,3-dihydro-imidazol-2-one (obtained in example 8, 100 mg) by alkylation with 2-chloromethylpyridine hydrochloride (73 mg) with the following modification: 2.5 equivalents of NaH dispersion (42 mg) was used such as to compensate for the HCl content in the alkylating agent. 1-Adamantan-2-yl-4-isopropyl-3-pyridin-2-ylmethyl-1,3-dihydro-imidazol-2-one was obtained as a light yellow gum (64 mg). MS (ESI): 352.2 (MH+).

Workup

  1. custom1—This material was obtained

Sources & evidence

ORD record
ord-84ed030dbac04c7e90a0b72b8090d965
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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