Bromomethylcyclopropane → HCID 57495526, compound

HRID 1092310Notes

Reaction equation

HRID 1092310 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[N:11]1[CH:15]=[C:14]([CH:16]3[CH2:18][CH2:17]3)[NH:13][C:12]1=[O:19])[CH2:8]2.Br[CH2:21][CH:22]1[CH2:24][CH2:23]1>>[CH:1]12[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH:2]1[N:11]1[CH:15]=[C:14]([CH:16]3[CH2:17][CH2:18]3)[N:13]([CH2:21][CH:22]3[CH2:24][CH2:23]3)[C:12]1=[O:19])[CH2:10]2

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 24964792HCID 24964792, compound

Product 1

HCID 57495526HCID 57495526, compound

Procedure

This material was obtained in analogy to the procedure outlined in example 23 from 1-adamantan-2-yl-4-cyclopropyl-1,3-dihydro-imidazol-2-one (obtained in example 15, 100 mg) by alkylation with bromomethylcyclopropane (57 mg). 1-Adamantan-2-yl-4-cyclopropyl-3-cyclopropylmethyl-1,3-dihydro-imidazol-2-one was obtained as a light yellow oil (11 mg). MS (EI): 312.3 (M+).

Workup

  1. customThis material was obtained in analogy to the procedure

Sources & evidence

ORD record
ord-5bb483ed5d5c4a8699013c48ad5c7948
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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