1-(Bromomethyl)-2-(trifluoromethyl)benzene → 3-Cyclopropyl-4-methyl-1-(2-trifluoromethyl-benzyl)-1,3-dihydro-imidazol-2-one

HRID 1092313Notes

Reaction equation

HRID 1092313 reaction equation
[CH:1]1([N:4]2[C:8]([CH3:9])=[CH:7][NH:6][C:5]2=[O:10])[CH2:3][CH2:2]1.[F:11][C:12]([F:22])([F:21])[C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15]Br>>[CH:1]1([N:4]2[C:8]([CH3:9])=[CH:7][N:6]([CH2:15][C:14]3[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=3[C:12]([F:11])([F:21])[F:22])[C:5]2=[O:10])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 55300021Cyclopropyl-5-methyl-1,3-dihydro-imidazol-2-one

Product 1

HCID 249654993-Cyclopropyl-4-methyl-1-(2-trifluoromethyl-benzyl)-1,3-dihydro-imidazol-2-one

Procedure

This material was obtained in analogy to the procedure outlined in example 28, Step B] from 1-cyclopropyl-5-methyl-1,3-dihydro-imidazol-2-one (obtained in example 28, step A), 150 mg) by alkylation with 2-trifluoromethylbenzyl bromide (285 mg). 3-Cyclopropyl-4-methyl-1-(2-trifluoromethyl-benzyl)-1,3-dihydro-imidazol-2-one was obtained as a colorless liquid (121 mg). MS (ESI): 297.1 (MH+).

Workup

  1. customThis material was obtained in analogy to the procedure

Sources & evidence

ORD record
ord-2b4ed83d93404f67a61e144507c8e323
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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