1-(Bromomethyl)-2-(trifluoromethyl)benzene → 3-Cyclopropyl-4-methyl-1-(2-trifluoromethyl-benzyl)-1,3-dihydro-imidazol-2-one

Participants

Reaction Steps

This material was obtained in analogy to the procedure outlined in example 28, Step B] from 1-cyclopropyl-5-methyl-1,3-dihydro-imidazol-2-one (obtained in example 28, step A), 150 mg) by alkylation with 2-trifluoromethylbenzyl bromide (285 mg). 3-Cyclopropyl-4-methyl-1-(2-trifluoromethyl-benzyl)-1,3-dihydro-imidazol-2-one was obtained as a colorless liquid (121 mg). MS (ESI): 297.1 (MH+).

Provenance & Evidence