Methyl iodide → HCID 24965502, compound

HRID 1092317Notes

Reaction equation

HRID 1092317 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[N:11]1[CH:15]=[C:14]([CH2:16][C:17]([F:20])([F:19])[F:18])[NH:13][C:12]1=[O:21])[CH2:8]2.I[CH3:23]>>[CH:1]12[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH:2]1[N:11]1[CH:15]=[C:14]([CH2:16][C:17]([F:20])([F:18])[F:19])[N:13]([CH3:23])[C:12]1=[O:21])[CH2:10]2

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 24964793HCID 24964793, compound

Product 1

HCID 24965502HCID 24965502, compound

Procedure

This material was obtained in analogy to the procedure outlined in example 23 from 1-adamantan-2-yl-4-(2,2,2-trifluoro-ethyl)-1,3-dihydro-imidazol-2-one (obtained in example 16, 100 mg) by alkylation with iodomethane (71 mg). 1-Adamantan-2-yl-3-methyl-4-(2,2,2-trifluoro-ethyl)-1,3-dihydro-imidazol-2-one was obtained as a light yellow solid (72 mg). MS (EI): 314.2 (M+).

Workup

  1. customThis material was obtained in analogy to the procedure

Sources & evidence

ORD record
ord-2762920ccb9b448285c218ba06201e22
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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