Bromomethylcyclopropane → HCID 24965505, compound

HRID 1092320Notes

Reaction equation

HRID 1092320 reaction equation
[CH:1]([C:4]1[NH:5][C:6](=[O:19])[N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([F:18])([F:17])[F:16])[CH:8]=1)([CH3:3])[CH3:2].Br[CH2:21][CH:22]1[CH2:24][CH2:23]1>>[CH:22]1([CH2:21][N:5]2[C:4]([CH:1]([CH3:3])[CH3:2])=[CH:8][N:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:15]([F:16])([F:18])[F:17])[C:6]2=[O:19])[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 24964796HCID 24964796, compound

Product 1

HCID 24965505HCID 24965505, compound

Procedure

This material was obtained in analogy to the procedure outlined in example 23 from 4-isopropyl-1-(2-trifluoromethyl-phenyl)-1,3-dihydro-imidazol-2-one (obtained in example 19, 50 mg) by alkylation with bromomethylcyclopropane (25 mg). 3-Cyclopropylmethyl-4-isopropyl-1-(2-trifluoromethyl-phenyl)-1,3-dihydro-imidazol-2-one was obtained as a colorless oil (11 mg). MS (ESI): 325.3 (MH+).

Workup

  1. customThis material was obtained in analogy to the procedure

Sources & evidence

ORD record
ord-f0d8a35061174620814682ad523d5d02
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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