(Bromomethyl)cyclobutane → HCID 24965852, compound

HRID 1092324Notes

Reaction equation

HRID 1092324 reaction equation
[CH2:1]([C:5]1[NH:6][C:7](=[O:20])[N:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]([F:19])([F:18])[F:17])[CH:9]=1)[CH:2]([CH3:4])[CH3:3].Br[CH2:22][CH:23]1[CH2:26][CH2:25][CH2:24]1>>[CH:23]1([CH2:22][N:6]2[C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:9][N:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[C:16]([F:19])([F:17])[F:18])[C:7]2=[O:20])[CH2:26][CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 2734658(Bromomethyl)cyclobutaneHCID 24964795HCID 24964795, compound

Product 1

HCID 24965852HCID 24965852, compound

Procedure

This material was obtained in analogy to the procedure outlined in example 23 from 4-isobutyl-1-(2-trifluoromethyl-phenyl)-1,3-dihydro-imidazol-2-one (obtained in example 18, 200 mg) by alkylation with bromomethylcyclobutane (115 mg). 3-Cyclobutylmethyl-4-isobutyl-1-(2-trifluoromethyl-phenyl)-1,3-dihydro-imidazol-2-one was obtained as a light yellow oil (9 mg). MS (ESI): 353.2 (MH+).

Workup

  1. customThis material was obtained in analogy to the procedure

Sources & evidence

ORD record
ord-217d82e1f92c425da7fffd47564add9e
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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