Bromomethylcyclopropane → HCID 24965855, compound

HRID 1092326Notes

Reaction equation

HRID 1092326 reaction equation
[CH2:1]([C:5]1[NH:6][C:7](=[O:18])[N:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])[CH:9]=1)[CH:2]([CH3:4])[CH3:3].Br[CH2:20][CH:21]1[CH2:23][CH2:22]1>>[CH:21]1([CH2:20][N:6]2[C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:9][N:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[O:16][CH3:17])[C:7]2=[O:18])[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 24965854HCID 24965854, compound

Product 1

HCID 24965855HCID 24965855, compound

Procedure

This material was obtained in analogy to the procedure outlined in example 23 from 4-isobutyl-1-(2-methoxy-phenyl)-1,3-dihydro-imidazol-2-one (obtained in example 42, 150 mg) by alkylation with bromomethylcyclopropane (90 mg). 3-Cyclopropylmethyl-4-isobutyl-1-(2-methoxy-phenyl)-1,3-dihydro-imidazol-2-one was obtained as a colorless oil (52 mg). MS (ESI): 301.2 (MH+).

Workup

  1. customThis material was obtained in analogy to the procedure

Sources & evidence

ORD record
ord-8b79cbe8bebd43bca8487be3e8295dac
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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