Bromomethylcyclopropane → HCID 24965857, compound

HRID 1092327Notes

Reaction equation

HRID 1092327 reaction equation
[CH2:1]([C:5]1[NH:6][C:7](=[O:21])[N:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][C:17]([F:20])([F:19])[F:18])[CH:9]=1)[CH:2]([CH3:4])[CH3:3].Br[CH2:23][CH:24]1[CH2:26][CH2:25]1>>[CH:24]1([CH2:23][N:6]2[C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:9][N:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[O:16][C:17]([F:20])([F:18])[F:19])[C:7]2=[O:21])[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 24965856HCID 24965856, compound

Product 1

HCID 24965857HCID 24965857, compound

Procedure

This material was obtained in analogy to the procedure outlined in example 23 from 4-isobutyl-1-(2-trifluoromethoxy-phenyl)-1,3-dihydro-imidazol-2-one (obtained in example 44, 60 mg) by alkylation with bromomethylcyclopropane (35 mg). 3-Cyclopropylmethyl-4-isobutyl-1-(2-trifluoromethoxy-phenyl)-1,3-dihydro-imidazol-2-one was obtained as a light yellow oil (11 mg). MS (ESI): 355.2 (MH+).

Workup

  1. customThis material was obtained in analogy to the procedure

Sources & evidence

ORD record
ord-d09a0caa54114ec999d36ea7c50979b4
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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