Diisobutylaluminumhydride → HCID 53629097, compound

HRID 1092348Notes

Reaction equation

[CH2:1]([NH:3][C:4]1([C:9]#[N:10])[CH2:8][CH2:7][CH2:6][CH2:5]1)[CH3:2].[H-].C([Al+]CC(C)C)C(C)C>>[NH2:10][CH2:9][C:4]1([NH:3][CH2:1][CH3:2])[CH2:8][CH2:7][CH2:6][CH2:5]1

Participants

Reactant 2

HCID 21225700Diisobutylaluminumhydride

HCID 216789691-(Ethylamino)cyclopentane-1-carbonitrile

Product 1

HCID 53629097HCID 53629097, compound

Procedure

This material was obtained in analogy to example 65 step a, from 1-ethylamino-cyclopentanecarbonitrile (7.5 g), synthesis described in: J. Med. Chem.; 1969; 473, by reduction with diisobutylaluminiumhydride (20% in toluene, 282.6 mL) as an oil (6.55 g) and directly used in the next reaction step.

Workup

customThis material was obtained in analogy to example 65 step a,

Sources & evidence

ORD record: ord-5b45265580664c37b71fb8a29339d42b
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08129423B2

Reaction notes

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