3-(aminomethyl)-N,N-dibenzyloxetan-3-amine → 3-(aminomethyl)-N-benzyloxetan-3-amine

HRID 1092350Notes

Reaction equation

HRID 1092350 reaction equation
[NH2:1][CH2:2][C:3]1([N:7](CC2C=CC=CC=2)[CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:6][O:5][CH2:4]1>CO.[Pd]>[NH2:1][CH2:2][C:3]1([NH:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:6][O:5][CH2:4]1

Participants

4

Reactant 1

HCID 574158213-(aminomethyl)-N,N-dibenzyloxetan-3-amine

Product 1

HCID 574158553-(aminomethyl)-N-benzyloxetan-3-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To (3-Aminomethyl-oxetan-3-yl)-dibenzyl-amine in methanol (10 ml) was added a catalytic amount of 10% Pd/C and the reaction mixture was then stirred at RT under an atmosphere of H2 for 8 h. The catalyst was removed by filtration, the filtrate concentrated under reduced pressure to provide the title compound (90 mg) as colorless oil, MS (EI): 192 (M+).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-fa9cd0f963544b26b95f936a2f01a27f
Source dataset
uspto-grants-2012_03
Patent number
US08129423B2

Reaction notes

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