反应详情

0.500 g (2.67 mmol) of 2-(2-aminophenyl)-3-methyl-2-cyclopenten-1-one, 0.253 g (3.204 mmol) of pyridine, 0.584 g (2.67 mmol) of 2-mesitylenesulfonyl chloride), and 2 mL of M.C (methylene chloride) were loaded to a 20 mL vial, and then reacted for 12 hours. 10 mL of M.C and 4 mL of 2 N HCl were added to the reaction product. The resultant organic layer is collected and then dried over MgSO4 to remove water. The solvent contained in the dried product was removed using a rotary vacuum evaporator. The obtained solid was washed with 10 mL of diethyl ether and filtered using a glass filter. The filtered product was dried in vacuum to remove the solvent that had remained therein (0.790 g, 80%).

1. customreacted for 12 hours
2. customThe resultant organic layer is collected
3. dry with materialdried over MgSO4
4. customto remove water
5. customwas removed
6. customa rotary vacuum evaporator
7. washThe obtained solid was washed with 10 mL of diethyl ether
8. filtrationfiltered
9. filtrationfilter
10. customThe filtered product was dried in vacuum
11. customto remove the solvent that