Pyridine → HCID 66593821, compound

HRID 1092457Notes

Reaction equation

HRID 1092457 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[C:10](=[O:15])[CH2:11][CH2:12][C:13]=1[CH3:14].N1C=CC=CC=1.[C:22]1([CH3:32])[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=1>>[C:22]1([CH3:32])[CH:27]=[CH:26][C:25]([S:28]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=2[C:9]2[C:10](=[O:15])[CH2:11][CH2:12][C:13]=2[CH3:14])(=[O:30])=[O:29])=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 66593482HCID 66593482, compound

Product 1

HCID 66593821HCID 66593821, compound

Procedure

0.700 g (3.14 mmol) of 2-(2-amino-5-fluorophenyl)-3-methyl-2-cyclopenten-1-one, 0.298 g (3.76 mmol) of pyridine, 0.598 g (3.76 mmol) of p-toluenesulfonyl chloride, and 3 mL of M.C were loaded to a 20 mL vial, and then reacted for 12 hours. The work-up was the same as in Example 7 (1.000 g, 85%).

Workup

  1. customreacted for 12 hours

Sources & evidence

ORD record
ord-4c5f1efe2eba43d4900e354341c0422b
Source dataset
uspto-grants-2012_03
Patent number
US08129488B2

Reaction notes

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