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HRID1092563

反应详情

EQUATION

反应方程式

HRID 1092563 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：C1COCCO1
HCID31275

1,4-Dioxane

C4H8O2

结构：CC(C)C(C(=O)N1C[C@H]2CC[C@H](NC(=O)OC(C)(C)C)[C@H]2C1)c1ccccc1
HCID66590911

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)C(C(=O)N1C[C@H]2CC[C@H](N)[C@H]2C1)c1ccccc1.Cl
HCID66590901

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOCC
溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

tert-Butyl(3aR,4S,6aS)-2-(3-methyl-2-phenylbutanoyl)octahydrocyclopenta[c]pyrrol-4-ylcarbamate (39 mg, 0.101 mmol) from Step C was combined with 4 M HCl in dioxane (5 mL, 20.00 mmol) in ether (5 mL). After about 2 hours, the solvent was removed in vacuo to give 1-((3aR,4S,6aS)-4-aminohexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-methyl-2-phenylbutan-1-one hydrochloric acid salt which was used in the next step without additional purification: MS (ESI+) m/z 287 (M+H)+.

WORKUP

后处理

  1. customthe solvent was removed in vacuo