Hydrochloric Acid → HCID 66588663, compound

HRID 1092726Notes

Reaction equation

HRID 1092726 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][C:11]1[CH2:12][C:13]2[C:18]([CH2:19][C:20]=1OC)=[CH:17][CH:16]=[C:15]([O:23][CH3:24])[C:14]=2[O:25][CH3:26])(C)(C)C.[ClH:28]>CO>[ClH:28].[CH3:26][O:25][C:14]1[C:13]2[CH2:12][CH:11]3[C:20]([CH2:19][C:18]=2[CH:17]=[CH:16][C:15]=1[O:23][CH3:24])=[N:7][CH2:8][CH2:9][CH2:10]3

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57608042HCID 57608042, compound

Product 1

HCID 66588663HCID 66588663, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound 8 (1.52 g from the previous step) was dissolved in MeOH (20 mL). 37% HCl (3.5 mL) was added, and the mixture was refluxed for 4 h. The volatiles were removed in vacuo, using toluene to azeotropically remove the water. This provided impure compound 9 (0.89 g) as an yellow oil.

Workup

  1. temperaturethe mixture was refluxed for 4 h
  2. customThe volatiles were removed in vacuo
  3. customto azeotropically remove the water

Sources & evidence

ORD record
ord-53fa1df86f694068934dd514fa674ea0
Source dataset
uspto-grants-2012_03
Patent number
US08129530B2

Reaction notes

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