HCID 86627645, compound → HCID 86627646, compound

HRID 1092756Notes

Reaction equation

HRID 1092756 reaction equation
[Cl:1]C(OC([N:7]1[CH2:12][CH:11]=[C:10]([C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[NH:20][C:21]([C:23]2[CH:28]=[CH:27][N:26]=[C:25]([Cl:29])[CH:24]=2)=[O:22])[CH2:9][CH2:8]1)=O)C>CO>[ClH:1].[Cl:29][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][N:26]=1)[C:21]([NH:20][C:14]1[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:13]=1[C:10]1[CH2:11][CH2:12][NH:7][CH2:8][CH:9]=1)=[O:22]

Participants

3

Reactant 1

HCID 86627645HCID 86627645, compound

Product 1

HCID 86627646HCID 86627646, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Crude 4-{5-chloro-2-[(2-chloro-pyridine-4-carbonyl)-amino]phenyl}-3,6-dihydro-2H-pyridine-1-carboxylic acid 1-chloro-ethyl ester (550 mg) was dissolved in methanol (25 ml) in and heated to reflux for 16 hours. Evaporation afforded the crude title product (465 mg). Retention Time HPLC 1.48 min; MS (ES+) 350, 348 (M+H+).

Workup

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. customEvaporation

Sources & evidence

ORD record
ord-2f1f9c3d6f544c2385a526198379b0c5
Source dataset
uspto-grants-2012_03
Patent number
US08129534B2

Reaction notes

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