Benzoate → Benzoate maleate

HRID 1092780Notes

Reaction equation

HRID 1092780 reaction equation
[C:1]([O-:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]([OH:17])(=[O:16])/[CH:11]=[CH:12]\[C:13]([OH:15])=[O:14]>C(OCC)(=O)C>[C:10]([OH:17])(=[O:16])/[CH:11]=[CH:12]\[C:13]([OH:15])=[O:14].[C:1]([OH:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 242BenzoateHCID 444266Maleic Acid

Product 1

HCID 68560292Benzoate maleate

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

In 3 mL of ethyl acetate was dissolved 0.25 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinyl=benzoate, and 0.07 g of maleic acid was added thereto, after which the resulting mixture was heated to effect dissolution. The reaction mixture was cooled and the crystals precipitated were collected by filtration to obtain 0.15 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinyl=benzoate maleate.

Workup

  1. additionwas added
  2. temperatureafter which the resulting mixture was heated
  3. dissolutiondissolution
  4. temperatureThe reaction mixture was cooled
  5. customthe crystals precipitated
  6. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-971f919c760e4f7f91b20193cba1e61d
Source dataset
uspto-grants-2012_03
Patent number
US08129535B2

Reaction notes

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