HCID 66590284, compound → HCID 56849261, compound

HRID 1092805Notes

Reaction equation

[CH:1]1([N:4]([CH2:43][C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([Cl:50])[C:45]=2[Cl:51])[C:5]([C:7]2[C@@H:8]([CH2:38][O:39]COC)[N:9](C(OC(C)(C)C)=O)[CH2:10][CH2:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][O:22][C:23]3[C:28]([Cl:29])=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:30])=[CH:15][CH:14]=2)=[O:6])[CH2:3][CH2:2]1>Cl.CO>[CH:1]1([N:4]([CH2:43][C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([Cl:50])[C:45]=2[Cl:51])[C:5]([C:7]2[C@@H:8]([CH2:38][OH:39])[NH:9][CH2:10][CH2:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][O:22][C:23]3[C:28]([Cl:29])=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:30])=[CH:15][CH:14]=2)=[O:6])[CH2:3][CH2:2]1

Participants

Conditions

Temperature: 55 °C

Procedure

9A (52 mg, 65 μmol) as prepared in Example 9, Step A, was dissolved in 1.25 M HCl in methanol and stirred at 55° C. for 1 hour. Solvent was removed under vacuum. The residue was purified by preparatory LCMS (water:acetonitrile, 45-60%) to give Compound 6 (25 mg, 61%). ESI-MS:m/z 635.2 (M+H)+.

Workup

customSolvent was removed under vacuum
customThe residue was purified by preparatory LCMS (water:acetonitrile, 45-60%)

Sources & evidence

ORD record: ord-2736ff96efdf4dc781b19760f871ecbf
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08129538B1

Reaction notes

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