Hydrochloric Acid → 2-Bromo-4-nitro-1H-imidazole

Solution of 2-bromo-1-methoxymethyl-4-nitroimidazole (11.17 g), methanol (10 ml) and 5N hydrochloric acid (60 ml) was stirred under refluxing condition for 2.5 hours. After being let to stand the reaction mixture at a room temperature for 24 hours, the mixture was stirred for 1 hour under ice-cooling condition, the precipitated crystals were collected by filtration, and dried at 50° C. under a reduced pressure for 24 hours, there was obtained 2-bromo-4-nitroimidazole (6.0 g, yield: 66.0%) of white powdery product.

1. temperatureunder refluxing condition for 2.5 hours
2. customat a room temperature
3. customfor 24 hours
4. temperaturecooling condition
5. filtrationthe precipitated crystals were collected by filtration
6. customdried at 50° C. under a reduced pressure for 24 hours

ORD record

ord-cc471949238b4a308ac210e8c9dcbb5d

Source dataset

uspto-grants-2012_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08129544B2