Sodium Carbonate → HCID 66588493, compound

HRID 1092936Notes

Reaction equation

HRID 1092936 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:17])[CH2:12][S:11][C:10]([NH:13][C:14](=[O:16])[CH3:15])=[N:9]2)=[CH:4][CH:3]=1.[CH3:18][S:19](Cl)(=[O:21])=[O:20].C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[CH3:18][S:19]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([CH3:17])[CH2:12][S:11][C:10]([NH:13][C:14](=[O:16])[CH3:15])=[N:9]2)=[CH:6][CH:7]=1)(=[O:21])=[O:20]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 31297Methanesulfonyl chlorideHCID 66588491HCID 66588491, compound

Product 1

HCID 66588493HCID 66588493, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

N-[4-(4-Amino-phenyl)-4-methyl-thiazol-2-yl]-acetamide (0.05 g, 0.20 mmol) is dissolved in dimethylformamide (1 ml) and treated by a solution of methylsulfonyl chloride (0.0232 g, 0.20 mmol) in dry dimethylformamide (1 ml) followed by 2M aqueous sodium carbonate solution (0.20 ml, 0.40 mmol). The reaction mixture is stirred at room temperature for 18 hours. The solvent is removed in vacuo and the residue is purified by chromatography to give the title compound. MH+ (ESMS): 326.1

Workup

  1. customThe solvent is removed in vacuo
  2. customthe residue is purified by chromatography

Sources & evidence

ORD record
ord-e80f01a7789d4a8f950d329197b5d15d
Source dataset
uspto-grants-2012_03
Patent number
US08129541B2

Reaction notes

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