Ethyl isocyanate → 1-Ethyl-3-[5-(4-methoxy-phenyl)-4-methyl-thiazol-2-yl]urea

HRID 1092948Notes

Reaction equation

HRID 1092948 reaction equation
[CH2:1]([N:3]=[C:4]=[O:5])[CH3:2].[CH3:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[S:18][C:17]([NH2:19])=[N:16][C:15]=2[CH3:20])=[CH:10][CH:9]=1>O1CCOCC1>[CH2:1]([NH:3][C:4]([NH:19][C:17]1[S:18][C:14]([C:11]2[CH:12]=[CH:13][C:8]([O:7][CH3:6])=[CH:9][CH:10]=2)=[C:15]([CH3:20])[N:16]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 282765965-(4-Methoxyphenyl)-4-methyl-2-thiazolamine

Product 1

HCID 858617301-Ethyl-3-[5-(4-methoxy-phenyl)-4-methyl-thiazol-2-yl]urea

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Ethyl isocyanate (1.2 ml, 14.18 mmol) is added to 5-(4-methoxy-phenyl)-4-methyl-thiazol-2-ylamine (Example 28b) (1.56 g, 7.09 mmol) in dioxane (100 ml). After 5 hours at 85° C. the reaction mixture is concentrated to yield 1-ethyl-3-[5-(4-methoxy-phenyl)-4-methyl-thiazol-2-yl]urea as a brown solid.

Workup

  1. concentrationAfter 5 hours at 85° C. the reaction mixture is concentrated

Sources & evidence

ORD record
ord-985d95cf92a144c4b7e365960b4ab0a8
Source dataset
uspto-grants-2012_03
Patent number
US08129541B2

Reaction notes

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