HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl isocyanate → 1-Ethyl-3-[5-(4-methoxy-phenyl)-4-methyl-thiazol-2-yl]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl isocyanate | HCID 8022 | — |
| Reactant | 5-(4-Methoxy-phenyl)-4-methyl-thiazol-2-ylamine | HCID 28276596 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Ethyl-3-[5-(4-methoxy-phenyl)-4-methyl-thiazol-2-yl]urea | HCID 85861730 | — |
Reaction Steps
Ethyl isocyanate (1.2 ml, 14.18 mmol) is added to 5-(4-methoxy-phenyl)-4-methyl-thiazol-2-ylamine (Example 28b) (1.56 g, 7.09 mmol) in dioxane (100 ml). After 5 hours at 85° C. the reaction mixture is concentrated to yield 1-ethyl-3-[5-(4-methoxy-phenyl)-4-methyl-thiazol-2-yl]urea as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08129541B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-985d95cf92a144c4b7e365960b4ab0a8 |
| Source note | uspto-grants-2012_03 |