3-Fluoro-4-(trifluoromethyl)benzaldehyde → N-[5-(4-Methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

HRID 1092970Notes

Reaction equation

HRID 1092970 reaction equation
F[C:2]1[CH:3]=[C:4]([C:12]2[S:16][C:15]([NH:17][C:18](=[O:20])[CH3:19])=[N:14][C:13]=2[CH3:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])(=[O:10])=[O:9].FC1C=C(C=CC=1[C:31]([F:34])([F:33])[F:32])C=O>>[CH3:11][S:8]([C:7]1[CH:6]=[CH:5][C:4]([C:12]2[S:16][C:15]([NH:17][C:18](=[O:20])[CH3:19])=[N:14][C:13]=2[CH3:21])=[CH:3][C:2]=1[C:31]([F:34])([F:33])[F:32])(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 27375373-Fluoro-4-(trifluoromethyl)benzaldehydeHCID 57351276N-[5-(3-fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]acetamide

Product 1

HCID 70684690N-[5-(4-Methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

Procedure

The title compound is prepared by an analogous procedure to N-[5-(3-fluoro-4-methane-sulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Example 64) by replacing 3,4-difluoro-benzaldehyde with 3-fluoro-4-trifluoromethylbenzaldehyde.

Sources & evidence

ORD record
ord-7b0d0a8cfad645048189fc8d293648c4
Source dataset
uspto-grants-2012_03
Patent number
US08129541B2

Reaction notes

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