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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1092970Generated: October 25, 2026

3-Fluoro-4-(trifluoromethyl)benzaldehyde → N-[5-(4-Methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

https://huagongshe.com/reaction/1092970

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluoro-4-(trifluoromethyl)benzaldehydeHCID 2737537—
ReactantN-[5-(3-fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]acetamideHCID 57351276—
ProductN-[5-(4-Methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-acetamideHCID 70684690—

Reaction Steps

The title compound is prepared by an analogous procedure to N-[5-(3-fluoro-4-methane-sulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Example 64) by replacing 3,4-difluoro-benzaldehyde with 3-fluoro-4-trifluoromethylbenzaldehyde.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08129541B2
Source datasetuspto-grants-2012_03
ORD IDord-7b0d0a8cfad645048189fc8d293648c4
Source noteuspto-grants-2012_03