反应详情

To a mixture of ethyl 10-(benzyl(ethyl)amino)-4-oxo-3-((phenylcarbonyl)oxy)-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a]azepine-2-carboxylate (120 mg, 0.233 mmol) in methanol (5 mL) was added 1N HCl (0.256 mL, 0.256 mmol) followed by Pd/C (24.77 mg, 0.023 mmol) and the mixture stirred under 1 atm hydrogen for 18 h. The mixture was filtered and the solids thoroughly washed with dichloromethane. The filtrate was concentrated under reduced pressure and dried under high vacuum overnight to afford the title compound.

1. filtrationThe mixture was filtered
2. washthe solids thoroughly washed with dichloromethane
3. concentrationThe filtrate was concentrated under reduced pressure
4. customdried under high vacuum overnight