反应详情

6-Chloro-1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidine (0.20 g, 0.493 mmol) is treated with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole (0.119 g, 0.74 mmol), aq. Na2CO3 (0.52 mL, 2M), and tetrakis triphenylphosphine palladium (20 mg) in 1:1 toluene:ethanol. The reaction mixture is heated in a microwave at 120 C for 60 min. Aq. workup followed by RP HPLC (H2O, CH3CN, TFA) gives the title compound as a white solid (60 mg). MS m/s=487.2 (M+H)

1. temperatureThe reaction mixture is heated in a microwave at 120 C for 60 min