Hydrazine → HCID 86761505, compound

HRID 1093277Notes

Reaction equation

HRID 1093277 reaction equation
C(N1C[CH2:12][CH:11]([N:14]2[C:18]3=[N:19][C:20]([Cl:31])=[N:21][C:22]([N:23]4[CH2:29][CH:28]5[O:30][CH:25](CC5)[CH2:24]4)=[C:17]3[CH:16]=[N:15]2)CC1)C1C=CC=CC=1.[CH2:32](NN)[CH3:33].NN.C12OC(CC1)CNC2>>[Cl:31][C:20]1[N:19]=[C:18]2[N:14]([CH2:11][CH3:12])[N:15]=[CH:16][C:17]2=[C:22]([N:23]2[CH:29]3[CH2:32][CH2:33][CH:24]2[CH2:25][O:30][CH2:28]3)[N:21]=1

Participants

5

Reactant 4

HCID 9321HydrazineHCID 29062EthylhydrazineHCID 120692318-Oxa-3-azabicyclo[3.2.1]octaneHCID 75080606HCID 75080606, compound

Product 1

HCID 86761505HCID 86761505, compound

Procedure

A procedure similar to that used for the synthesis of 3-(1-(1-benzylpiperidin-4-yl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-8-oxa-3-azabicyclo[3.2.1]octane is used, using ethyl hydrazine as the hydrazine component and substituting 3-oxa-8-azabicyclo[3.2.1]octane for 8-oxa-3-azabicyclo[3.2.1]octane. (65%, MS=294.3 (M+H))

Sources & evidence

ORD record
ord-23505efbec57439a80cc7f7692f77014
Source dataset
uspto-grants-2012_03
Patent number
US08129371B2

Reaction notes

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