反应详情

50 mg (0.35 mmol) 3-amino-thiophene-2-carboxamide is dissolved in 3 mL dioxane. 52 mg (0.175 mmol, 0.5 eq) triphosgene is added and the mixture is heated at 80 C. After 30 min, TLC and LCMS indicate that the reaction is complete. The mixture is cooled down to RT and the resulting white precipitate is collected and washed with diethyl ether. Yield: 46 mg (0.27 mmol, 78%).

1. temperaturethe mixture is heated at 80 C
2. customthe resulting white precipitate is collected
3. washwashed with diethyl ether