Hydrochloric Acid → HCID 66593728, compound

HRID 1093315Notes

Reaction equation

HRID 1093315 reaction equation
C(OC(=O)[NH:7][C:8]([CH2:34][OH:35])([CH2:32][OH:33])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:13]([C:28]([F:31])([F:30])[F:29])[CH:12]=1)(C)(C)C.[ClH:37].O1CCOCC1>C(Cl)Cl>[ClH:37].[NH2:7][C:8]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:13]([C:28]([F:29])([F:30])[F:31])[CH:12]=1)([CH2:32][OH:33])[CH2:34][OH:35]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59407590HCID 59407590, compound

Product 1

HCID 66593728HCID 66593728, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 4-1 (490 mg) was dissolved in methylene chloride (7 ml), hydrogen chloride-containing dioxane (4 mol/l, 5 ml) was added, and the mixture was stirred at room temperature for 12 hr stirred for. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (370 mg) as a white powder.

Workup

  1. additionwas added
  2. stirringstirred for
  3. concentrationThe reaction mixture was concentrated
  4. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-7a0f01ff54c34a38867942bd2e8c4f70
Source dataset
uspto-grants-2012_03
Patent number
US08129361B2

Reaction notes

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