Hydrochloric Acid → HCID 66593742, compound

HRID 1093317Notes

Reaction equation

HRID 1093317 reaction equation
C(OC(=O)[NH:7][C:8]([CH2:35][OH:36])([CH2:33][OH:34])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[C:13]([C:29]([F:32])([F:31])[F:30])[CH:12]=1)(C)(C)C.[ClH:38].O1CCOCC1>C(Cl)Cl>[ClH:38].[NH2:7][C:8]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[C:13]([C:29]([F:30])([F:31])[F:32])[CH:12]=1)([CH2:33][OH:34])[CH2:35][OH:36]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59407736HCID 59407736, compound

Product 1

HCID 66593742HCID 66593742, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 5-1 (560 mg) was dissolved in methylene chloride (5 ml), hydrogen chloride-containing dioxane (4 mol/l 5 ml) was added, and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (410 mg) as a white powder.

Workup

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated
  3. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-7e9003635cf646fb8730364403c0e6e3
Source dataset
uspto-grants-2012_03
Patent number
US08129361B2

Reaction notes

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