Hydrochloric Acid → HCID 66594261, compound

HRID 1093319Notes

Reaction equation

HRID 1093319 reaction equation
C(OC(=O)[NH:7][C:8]1([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([O:32][C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[CH:27]=3)=[C:20]([C:39]([F:42])([F:41])[F:40])[CH:19]=2)[CH2:13][O:12]C(C)(C)[O:10][CH2:9]1)(C)(C)C.[ClH:44]>C(O)C>[ClH:44].[NH2:7][C:8]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([O:32][C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH:27]=2)=[C:20]([C:39]([F:40])([F:41])[F:42])[CH:19]=1)([CH2:9][OH:10])[CH2:13][OH:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59407771HCID 59407771, compound

Product 1

HCID 66594261HCID 66594261, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

Compound 7-1 (850 mg) was dissolved in ethanol (15 ml), concentrated hydrochloric acid (2 ml) was added, and the mixture was stirred at 80° C. for 1.5 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (603 mg) as a white powder.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-b4bda2757aa14a6b9d833dc48bc5116d
Source dataset
uspto-grants-2012_03
Patent number
US08129361B2

Reaction notes

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