Hydrochloric Acid → HCID 66594242, compound

HRID 1093322Notes

Reaction equation

HRID 1093322 reaction equation
C(OC(=O)[NH:7][C:8]1([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21](CCCC3CCCCC3)=[C:20]([C:33]([F:36])([F:35])[F:34])[CH:19]=2)[CH2:13][O:12]C(C)(C)[O:10][CH2:9]1)(C)(C)C.[ClH:38].[CH2:39]([OH:41])[CH3:40]>>[ClH:38].[NH2:7][C:8]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:41][CH2:39][CH2:40][CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[C:20]([C:33]([F:34])([F:35])[F:36])[CH:19]=1)([CH2:9][OH:10])[CH2:13][OH:12]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 66593876HCID 66593876, compound

Product 1

HCID 66594242HCID 66594242, compound

Conditions

Temperature
80 °C

Procedure

Compound 9-2 (760 mg) was dissolved in ethanol (15 ml), concentrated hydrochloric acid (3 ml) was added, and the mixture was stirred at 80° C. for 2.5 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (525 mg) as a white powder. MS(ESI)m/z: 404[M+H]

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-262d53da32904aff97934f14b046e652
Source dataset
uspto-grants-2012_03
Patent number
US08129361B2

Reaction notes

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