HCID 57704605, compound → HCID 57704618, compound

HRID 1093404Notes

Reaction equation

HRID 1093404 reaction equation
[C:1]([O:5][C:6](=[O:35])[NH:7][C:8]1([C:16]#[C:17][C:18]2[CH:23]=[CH:22][C:21]([O:24]CC3C=CC=CC=3)=[C:20]([CH:32]([F:34])[F:33])[CH:19]=2)[CH2:13][O:12][C:11]([CH3:15])([CH3:14])[O:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2]>O1CCOCC1.[C].[Pd]>[C:1]([O:5][C:6](=[O:35])[NH:7][C:8]1([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([CH:32]([F:34])[F:33])[CH:19]=2)[CH2:13][O:12][C:11]([CH3:15])([CH3:14])[O:10][CH2:9]1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 57704605HCID 57704605, compound

Product 1

HCID 57704618HCID 57704618, compoundYield 89.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 312751,4-DioxaneSolvent

Procedure

Compound 51-3 (11.1 g) was dissolved in 1,4-dioxane (250 ml), 10% palladium carbon (3.5 g) was added, and the mixture was stirred under a hydrogen atmosphere at room temperature for 3.5 hr. The reaction container was purged with nitrogen, the solution was filtered, and the filtrate was concentrated. The residue was suspended in a mixed solution of diisopropyl ether and hexane and collected by filtration to give the object product (8.17 g) as a white powder.

Workup

  1. customThe reaction container was purged with nitrogen
  2. filtrationthe solution was filtered
  3. concentrationthe filtrate was concentrated
  4. filtrationcollected by filtration

Sources & evidence

ORD record
ord-144e38dadf664c01a009acff13616277
Source dataset
uspto-grants-2012_03
Patent number
US08129361B2

Reaction notes

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