Hydrochloric Acid → HCID 86761515, compound

HRID 1093407Notes

Reaction equation

HRID 1093407 reaction equation
C(OC(=O)[NH:7][C:8]1([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][C:28]3[CH:33]=[CH:32][C:31]([O:34][C:35]([F:38])([F:37])[F:36])=[CH:30][CH:29]=3)=[C:20]([C:39]([F:42])([F:41])[F:40])[CH:19]=2)[CH2:13][O:12]C(C)(C)[O:10][CH2:9]1)(C)(C)C.[ClH:44]>C(O)C>[ClH:44].[NH2:7][C:8]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][C:28]2[CH:29]=[CH:30][C:31]([O:34][C:35]([F:36])([F:37])[F:38])=[CH:32][CH:33]=2)=[C:20]([C:39]([F:40])([F:41])[F:42])[CH:19]=1)([CH2:13][OH:12])[CH2:9][OH:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59407510HCID 59407510, compound

Product 1

HCID 86761515HCID 86761515, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

Compound 52-4 (790 mg) was dissolved in ethanol (15 ml), concentrated hydrochloric acid (1.5 ml) was added, and the mixture was stirred at 80° C. for 2 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (600 mg) as a white powder.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-e3436d4b65634970a678b0f0a849f275
Source dataset
uspto-grants-2012_03
Patent number
US08129361B2

Reaction notes

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