Hydrochloric Acid → HCID 66593896, compound
Reaction equation
C(OC(=O)[NH:7][C:8]1([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][C:28]3[CH:29]=[C:30]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[CH:31]=[CH:32][CH:33]=3)=[C:20]([C:40]([F:43])([F:42])[F:41])[CH:19]=2)[CH2:13][O:12]C(C)(C)[O:10][CH2:9]1)(C)(C)C.[ClH:45]>C(O)C>[ClH:45].[NH2:7][C:8]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][C:28]2[CH:29]=[C:30]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)[CH:31]=[CH:32][CH:33]=2)=[C:20]([C:40]([F:41])([F:42])[F:43])[CH:19]=1)([CH2:9][OH:10])[CH2:13][OH:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
Compound 79-5 (810 mg) was dissolved in ethanol (15 ml), concentrated hydrochloric acid (1.5 ml) was added, and the mixture was stirred at 80° C. for 1.5 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (530 mg) as a white powder.
Workup
- concentrationThe reaction mixture was concentrated
- washthe residue was washed with diethyl ether
Sources & evidence
- ORD record
- ord-efb378f38622494e8b6ad7c6cb606cd2
- Source dataset
- uspto-grants-2012_03
- Patent number
- US08129361B2
Reaction notes
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