Hydrochloric Acid → HCID 66594313, compound

HRID 1093499Notes

Reaction equation

C(OC(=O)[NH:7][C:8]1([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([N+:34]([O-:36])=[O:35])[CH:29]=3)=[C:20]([C:37]([F:40])([F:39])[F:38])[CH:19]=2)[CH2:13][O:12]C(C)(C)[O:10][CH2:9]1)(C)(C)C.[ClH:42]>C(O)C>[ClH:42].[NH2:7][C:8]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([N+:34]([O-:36])=[O:35])[CH:29]=2)=[C:20]([C:37]([F:38])([F:39])[F:40])[CH:19]=1)([CH2:13][OH:12])[CH2:9][OH:10]

Participants

Conditions

Temperature: 80 °C

Procedure

Compound 95-3 (587 mg) was dissolved in ethanol (15 ml), concentrated hydrochloric acid (1.5 ml) was added, and the mixture was stirred at 80° C. for 1 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (430 mg) as a white powder.

Workup

concentrationThe reaction mixture was concentrated
washthe residue was washed with diethyl ether

Sources & evidence

ORD record: ord-d482975ef2254848aa085f2d4f572490
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08129361B2

Reaction notes

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