Hydrochloric Acid → HCID 66593888, compound

HRID 1093513Notes

Reaction equation

[F:1][CH2:2][CH2:3][C:4]1([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[CH:23]=3)=[C:14]([C:29]([F:32])([F:31])[F:30])[CH:13]=2)[CH2:8][O:7]C(C)=[N:5]1.[ClH:33]>C(O)C>[ClH:33].[NH2:5][C:4]([CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[CH:23]=2)=[C:14]([C:29]([F:30])([F:31])[F:32])[CH:13]=1)([CH2:3][CH2:2][F:1])[CH2:8][OH:7]

Participants

Conditions

Temperature: 80 °C

Procedure

Compound 107-1 (230 mg) was dissolved in ethanol (15 ml), concentrated hydrochloric acid (2 ml) was added, and the mixture was stirred at 80° C. for 1 hr. The reaction mixture was concentrated, and the residue was washed with diisopropyl ether to give the object product (230 mg) as a white powder.

Workup

concentrationThe reaction mixture was concentrated
washthe residue was washed with diisopropyl ether

Sources & evidence

ORD record: ord-98f9c05ec3244c9eb33a76d445a454d8
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08129361B2

Reaction notes

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