HCID 66637581, compound → HCID 66637583, compound

HRID 1093924Notes

Reaction equation

HRID 1093924 reaction equation
C([O:8][C:9](=[O:28])[C@@H:10]([NH:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[C:24]([O:23][C:21]([NH:20][C@@H:10]([CH2:11][CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1)[C:9]([OH:28])=[O:8])=[O:22])([CH3:27])([CH3:25])[CH3:26]

Participants

4

Reactant 1

HCID 66637581HCID 66637581, compound

Product 1

HCID 66637583HCID 66637583, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of crude N-t-butoxycarbonyl-(S)-2-amino-5-(1-piperidinyl)pentanoic acid benzyl ester in ethanol (1.5 mL) was added 5% palladium-carbon (15.0 mg) and the mixture was stirred for 1 hour under hydrogen atmosphere. The insoluble materials were removed by suction filtration using selite, and the residue was washed with ethanol (10 mL). The filtrate and washings were collected and concentrated under vacuum to obtain crude N-t-butoxycarbonyl-(S)-2-amino-5-(1-piperidinyl)pentanoic acid (69.0 mg) as a colorless oily material.

Workup

  1. customThe insoluble materials were removed by suction filtration
  2. washthe residue was washed with ethanol (10 mL)
  3. customThe filtrate and washings were collected
  4. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-79a056aa26744c5c98ab7831cf24724e
Source dataset
uspto-grants-2012_03
Patent number
US08133864B2

Reaction notes

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