Piperidine → 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one

HRID 1093999노트

반응식

HRID 1093999 반응식
[O:1]=[C:2]1[N:6]([CH2:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][C:12](=[O:17])[CH2:11]3)[CH2:5][CH2:4][O:3]1.[CH3:18][C:19]1[CH:23]=[C:22]([CH3:24])[NH:21][C:20]=1[CH:25]=O.N1CCCCC1>C(O)C>[CH3:18][C:19]1[CH:23]=[C:22]([CH3:24])[NH:21][C:20]=1[CH:25]=[C:11]1[C:10]2[C:14](=[CH:15][CH:16]=[C:8]([CH2:7][N:6]3[CH2:5][CH2:4][O:3][C:2]3=[O:1])[CH:9]=2)[NH:13][C:12]1=[O:17]

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 2704653,5-Dimethyl-1H-pyrrole-2-carbaldehydeHCID 666361565-(2-Oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one

생성물 1

HCID 666363323-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one (4.3 mmoles), 3,5-dimethyl-1H-pyrrole-2-carbaldehyde (5.17 mmoles) and piperidine (3 mmoles) in ethanol (30 ml) is heated at reflux for 24 hours. The solid formed is filtered off, washed with ethanol, with water and then with ethanol and dried in vacuo to yield the title product.

후처리

  1. temperatureat reflux for 24 hours
  2. customThe solid formed
  3. filtrationis filtered off
  4. washwashed with ethanol, with water
  5. dry with materialwith ethanol and dried in vacuo

출처 및 근거

ORD 기록
ord-5a92623e9ef94385a2eb7c75576c415f
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08133889B2

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